The article argues for the need for an effective security service as one of the full-fledged headquarters units of the modern practice-oriented University operating in a competitive environment. The branch specificity of security in the sphere of higher professional education is analyzed, in particular, the existing advantages and additional «pain points» are revealed. It defines and explains the threat of reputational, information and property safety of the subjects of the higher school from competitors, its own employees and students. The possible negative impact of the implemented threats on the market position of the University is analyzed. It is proved that the main of them is the disloyal and irresponsible behavior of teachers, contributing to the deterioration of the business reputation of their employer in the eyes of the main consumers of its services, the Supervisory authorities of the state, other members of the national educational community. The main functional tasks of the security service and the powers necessary for their successful implementation are formulated and disclosed. The administrative, human, logistical and financial resources to be made available to it have been identified. The standard organizational structure of this division, the list of corporate local acts regulating its activity, and also system of external and internal administrative communications of security service are developed. A set of organizational, economic, psychological and other measures that can really motivate other departments, departments and departments of the University to actively interact with its security service is proposed. Methodical requirements to the organization of its practical activity are defined and proved, criteria for an assessment of efficiency of functioning are formulated.