This paper analyzes the main indicators of innovation activity in the Novosibirsk region. We consider such factors as the rating of innovation activity, the volume of innovative products, works and services, the number of personnel engaged in research and development in the Russian Federation, Siberian district and the Novosibirsk region, the cost of organizations' technological innovation by type of innovation activity in the Russian Federation, Siberian district and the Novosibirsk Region.The basic directions of innovation activity development were discovered, the pace of this development should be recognized as a positive, but not sufficient to accelerate the transition to the sixth techno-economic paradigm and preparing the conditions for the formation of the seventh techno-economic paradigm.The main priorities for the Novosibirsk region, development of which will increase the proportion of organizations that develop and introduce new technologies, corresponding of the sixth techno-economic paradigm, were considered.An attempt was made to assess the requirements and features of the formation of indicators of innovation activity corresponding formation of the seventh techno-economic paradigm. A number of indicators was offered to assess the conditions for the development of the sixth techno-economic paradigm and the formation of conditions for transition to the seventh techno-economic paradigm, such as the socially significant innovation.